Prolonged Course Of Antimicrobial Therapy
Prolonged course of antimicrobial therapy (PCAT) refers to taking antibiotics, antifungals, antivirals, or other antimicrobial agents for a longer period of time than what is typically prescribed for an infection. This kind of therapy is also known as long-term antibiotic therapy (LTAT). It is sometimes used for chronic infections which cannot be cured with a standard course of treatment, such as Lyme disease, chronic sinusitis, or certain skin infections. In some cases, PCAT is given to keep an infection under control even when the chances of a full cure are minimal. It is sometimes used in cases where a single short course of antibiotics fails to effectively treat an infection or when existing infection-fighting medicines become ineffective. At times, PCAT may be necessary to prevent a secondary infection or to deal with underlying health conditions that put the patient at greater risk of infection, such as a compromised immune system due to chemotherapy or HIV/AIDS. PCAT requires close monitoring since there is a heightened risk of side effects, particularly when used for long periods of time. The risk of antimicrobial resistance is also an issue that must be taken into consideration. As such, PCAT is typically only recommended in certain cases after careful evaluation. Patients at greatest risk for serious infections should also be closely monitored for potential complications when taking antimicrobials for an extended period of time.
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SHORT VERSUS PROLONGED COURSES OF ANTIMICROBIAL THERAPY …
Web Sep 30, 2021 Prolonged-course antimicrobial therapy did not significantly reduce the risk of recurrent infection or death compared with short-course antimicrobial therapy … ...
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COMPARISON OF A SHORT VERSUS LONG-COURSE ANTIBIOTIC …
Web Mar 1, 2023 The MEDLINE and Embase strategies were run simultaneously as a multi-file search in Ovid, and the results were de-duplicated using the Ovid duplication tool. We … ...
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Web Sep 27, 2020 Prolonged antibiotic treatment duration can increase adverse events and antibiotic resistance, 6, 7, 28 while inadequate antibiotic treatment may be associated … ...
Author Xiaoming Li, Chao Liu, Zhi Mao, Qinglin Li, Shuang Qi, Feihu ZhouPublish Year 2021
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Web Oct 4, 2021 Short-course antimicrobial therapy may be as effective as prolonged-course therapy for the treatment of patients with uncomplicated bloodstream infections … ...
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Web Dec 14, 2022 Evidence is emerging that for many common infections, short-course antibiotic therapy (1–7 days) can be equally as effective as traditional, longer courses … ...
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TREATMENT OF ACTINOMYCOSIS - UPTODATE
Web May 23, 2022 Management of actinomycosis often entails prolonged courses of antimicrobials. Surgical intervention may also be necessary in more complicated cases, … ...
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Web This study compared the clinical outcomes of short course (SC) and prolonged course (PC) antimicrobial therapy for IAI. Methods: This was a noninterventional, … ...
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Web Randomized controlled trials have demonstrated that shorter course therapy (≤7 days) is equally effective as longer course treatment for the most common bacterial infections in long-term care residents, including … ...
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Web Jan 17, 2022 We thank Hagiya and Otsuka 1 for their interest in our study on a short course of antimicrobial therapy in uncomplicated Pseudomonas aeruginosa … ...
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ORAL VERSUS INTRAVENOUS ANTIBIOTICS FOR BONE AND JOINT INFECTION
Web Jan 31, 2019 prolonged course of treatment with intra - ... parenteral antibiotic therapy4 However, . . . .” intravenous therapy is associated with substan-tial risks, inconvenience, … ...
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Web Aug 24, 2015 One study found that a three-day course of antibiotic therapy for patients with suspected HAP but a low Clinical Pulmonary Infection Score (CPIS) was associated … ...
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Web Oct 24, 2013 A prolonged duration of antibiotic therapy did not reduce the risk of bacteraemic relapse compared with shorter durations, even after adjusting for central line … ...
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Web The 2016 International Guidelines for the Management of Sepsis and Septic Shock recommend antibiotic therapy for 7–10 days for most patients with sepsis. However, … ...
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DURATION OF ANTIBIOTIC THERAPY: GENERAL PRINCIPLES - PHARMACY TIMES
Web Jul 24, 2017 Infected patients with no hemodynamic issues can be treated with short courses of antimicrobials. For example, community-acquired pneumonia (CAP) can be … ...
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Web Mar 2, 2021 A short course of antibiotic therapy (SC) demonstrated no difference in 90-day mortality compared with a prolonged course antibiotic therapy (PC) in patients … ...
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Web Dec 24, 2021 We compared the primary outcome (a composite of the rate of recurrent P. aeruginosa infection and mortality within 30 days after discontinuing antimicrobial … ...
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Web Dec 15, 2021 As suggested by the authors, their data, demonstrating the equivalence of treatment effects between the short and prolonged courses of antimicrobial therapy, … ...
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SHORT VERSUS PROLONGED COURSES OF ANTIMICROBIAL THERAPY FOR
Web Short versus prolonged courses of antimicrobial therapy for patients with uncomplicated Pseudomonas aeruginosa bloodstream infection: a retrospective study-authors' … ...
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Web A prolonged duration of antibiotic therapy did not reduce the relapse risk compared with shorter durations (adjusted hazard ratio 0.67; 95% CI 0.35-1.27). Similarly, each … ...
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Web Aug 14, 2019 Abstract Background: Guidelines recommend an antimicrobial therapy duration of four to seven days for intra-abdominal infections (IAIs). Despite evidence that … ...
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Web Mar 20, 2007 A major obstacle for such truly short-course therapy is the development of phenotypic antibiotic resistance in vivo. This phenomenon is common to all bacteria and … ...
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SHORT VERSUS PROLONGED COURSES OF ANTIMICROBIAL THERAPY FOR …
Web Sep 30, 2021 Short-course antimicrobial therapy could be as effective as prolonged-course therapy for uncomplicated P. aeruginosa BSI, according to propensity score … ...
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Web inappropriately prolonged antibiotic therapy (35). Collectively, these data suggest there is significant room for improvement in ensuring appropriate duration of antibiotic therapy … ...
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