R404A (also known as HFC-404A) is a near-azeotropic blend of 3 hydrofluorocarbons: R125, R134A, and R143A. It is commonly used as a refrigerant in commercial and residential refrigeration applications due to its lower Global Warming Potential (GWP) compared to R22. R404A has widespread usage in supermarkets and other large refrigeration systems, as well as being used as a retrofit for older R22 systems. It is also widely used in smaller applications such as under counter and domestic refrigerators, chest freezers, and vending machines. R404A also has potential applications in air conditioners and chillers. Its usage in air conditioners is limited due to its higher pressure and pressure drop compared to R410A. However, its efficiency is higher in certain scenarios such as when used in medium-temperature applications. Furthermore, its lower GWP has caused manufacturers of air conditioners to expand production of products using R404A as the new refrigerant. In addition to air conditioners, R404A is also used in chillers, heat pumps, and medium-temperature applications such as; beverage coolers, condensing units, comfort systems, and chillers for process cooling. Overall, R404A provides a viable and cost-effective alternative to R22 as a refrigerant option. It is a lower GWP and less expensive alternative, making it a great choice for both commercial and residential applications that can provide better energy efficiency and improved environmental accountability.