Myasthenia gravis is an autoimmune disorder that attacks the neuromuscular junction, which results in weak and fatigued muscles. A primary treatment for improving muscle strength and function is a prednisone course. Prednisone is a corticosteroid that directly suppresses inflammation and has a role in treating the symptoms of myasthenia gravis. Prednisone dosing varies, but most patients will start with a higher dose before tapering to a maintenance dose. After the initial course of treatment is complete, the healthcare provider will usually lower the prednisone dose to keep the symptoms at bay. Generally, the most common side effects from prednisone include appetite changes, insomnia, and mood swings. Other possible side effects include high blood pressure, weight gain, and muscle weakness. Myasthenia gravis can be a frustrating and challenging disease to manage, but prednisone is one of the drugs used to combat its symptoms. By reducing inflammation and improving muscle strength, a prednisone course can be an effective first line of treatment for fighting myasthenia gravis.